Simplified Monolithic Flow Cytometer Chip with Three-dimensional Hydrodynamic Focusing and Integrated Fiber-free Optics
نویسندگان
چکیده
A miniaturized flow cytometry incorporating both fluidic and optical systems has a great possibility for portable biochemical sensing or point-of-care diagnostics. This paper presents a simple microfluidic flow cytometer combining reliable 3D hydrodynamic focusing and optical detection without optical fibers in a monolithic architecture fabricated by a single photolithographic process. The vertical flow focusing is achieved by the optimized inlet geometry in a PDMS lid onto the substrate with detection channel and integrated optics. The simplified approach indicates the possibility to be applied as a portable platform of cytometer chip.
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تاریخ انتشار 2011